Flavoenol® is the dry extract of grape seeds (Vitis vinifera L.) standardized in flavonoids, the largest class of soluble grape polyphenols. Grape seeds flavonoids are responsible for many biological activities as cardioprotective, anti-oxidant, anti-inflammatory, antimicrobial, antiviral and neuroprotective (1).

Grape seeds are particularly rich in  oligomeric proanthocyanidins (OPC), strong antioxidants with healthy effects on cardiovascular system (2).

Fig.1. Proanthocyanidins: Oligomeric (left) and Polymeric (right)

Cardiovascular protection
Several studies demonstred that the consumption of grape derived products can have beneficial effects on cardiovascular system by improving the vascular and endothelial function, reduction of LDL oxidation and the modulation of the serum lipids levels and inflammatory processes.
The action is principally due to the OPCs, able to enanche the endogenous antioxidants effectiveness in reducing lipid peroxidation and determining the reduction of atheromatous plaques (1, 3).

Fig.2: Effect of grape seed supplementation ( G and HG groups) on the serum concentration of lipid peroxides in rats fed a control or high-fat diet (C and HF groups)

Flavoenol® grape seed dry extract is available with the following specifications:

≥ 95% Proanthocyanidins (Bate-Smith)
≥ 80,0% Polyphenols (Folin-Ciocalteu)
≥ 60,0% OPC (HPLC)

Flavoenol® complies the specifications according to Belfrit project directives.

Flavoenol® can be used as food supplement or in association with other active ingredients.
Daily doses of 200 o 400 mg have been considered safe by clinical studies (4).

1. V Georgiev, A. Ananga, V. Tsolova (2014). Recent Advances and Uses of Grape Flavonoids as Nutraceuticals. Nutrients. 6:391-415.
2.  F. Di Pierro (2016). Argomenti di Fitoterapia Biofarmaceutica. CEC Editore srl. Milano.
3. S. Choi, X. Zhang, J. Seo (2012). Suppression of oxidative stress by grape seed supplementation in rats. Nutrition Research and Practice. Nutr Res Pract; 6(1):3-8.
4. Sano A, et al. Beneficial effects of grape seed extract on malondialdehyde-modified LDL (2007). J Nutr Sci Vitaminol. 53:174-182.


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